Transplantation of syngenic bone marrow contaminated with NGFr-marked WEHI-3B cells: an improved model of leukemia relapse in mice
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چکیده
منابع مشابه
Leukemia relapse after allogeneic bone marrow transplantation: a review.
A LLOGENEIC BONE MARROW transplantation (BMT) is an effective treatment for hematologic malignancies.' More than 5,000 transplants are performed yearly worldwide. The increasing use of human leukocyte antigen (HLA) nonidentical donors, and HLA-matched unrelated donors will assure the continued growth in the use of this therapeutic modality.' Relapse of the underlying disease remains the most fr...
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Extramedullary relapse (EMR) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is relatively rare. The most commonly reported sites in acute lymphoblastic leukemia (ALL) patients after allo-HSCT are soft tissue and the central nervous system, and the gastrointestinal system is an uncommon site. We herein report a unique case with massive hematemesis resulting from gastrointes...
متن کاملImprovement of Spinal Cord Injury in Rat Model via Transplantation of Neural Stem Cells Derived From Bone Marrow
Abstract Background & Aims: Cell therapy is among the novel therapeutic methods effective in the treatment of spinal cord injuries. The aim of the present study was using neural stem cells (NSCs) in treating contusion spinal cord injury in rat model. Methods: Bone marrow stromal cells (BMSCs) were isolated from adult rats...
متن کامل[Bone marrow transplantation in leukemia].
Marrow grafting is now an established treatment for patients under the age of 50 with acute leukemia and a suitable marrow donor. For all patients who have relapsed at least once, marrow grafting offers the possibility of cure of approximately 20%-30% of these patients, which cannot be achieved by any other regimen yet reported. Although still somewhat controversial, it appears that marrow graf...
متن کاملEffect of IL-27 on activity of bone marrow NK cells of patient with B-chronic lymphocytic leukemia in vitro
Introduction: Functional defect in immune cells is the prominent feature in hematological malignancies that lead to the expansion of tumor cells. Using immunostimulatory cytokines is one of the new therapeutic approaches. This study aimed to investigate the effect of IL-27 on the activity of bone marrow-NK cells of chronic lymphocytic leukemia (CLL) patients in vitro. Materials and Methods: 10 ...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2000
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2401697